Childhood adversity is associated with altered or dysregulated stress reactivity; these altered patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control of stress responses, including the subgenual anterior cingulate cortex (sgACC), paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) and amygdala. However, the relationship between childhood adversity and the (...) resting-state connectivity of this central visceral network remains unclear. To this end, we examined relationships between childhood threat and childhood socioeconomic deprivation, the resting-state connectivity between our regions of interest (ROIs), and affective symptom severity and diagnoses. We recruited a transdiagnostic sample of young adult males and females (n= 100; mean age = 27.28,SD= 3.99; 59 females) with a full distribution of maltreatment history and symptom severity across multiple affective disorders. Resting-state data were acquired using a 7.2-min functional magnetic resonance imaging (fMRI) sequence; noted ROIs were applied as masks to determine ROI-to-ROI connectivity. Threat was determined by measures of childhood traumatic events and abuse. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education level). Covarying for age, race and sex, greater childhood threat was significantly associated with lower BNST-PVN, amygdala-sgACC and PVN-sgACC connectivity. No significant relationships were found between SED and resting-state connectivity. BNST-PVN connectivity was associated with the number of lifetime affective diagnoses. Exposure to threat during early development may entrain altered patterns of resting-state connectivity between these stress-related ROIs in ways that contribute to dysregulated neural and physiological responses to stress and subsequent affective psychopathology. (shrink)

Two cross-modal experiments provide partial support for O'Regan & Noë's (O&N's) claim that sensorimotor contingencies mediate perception. Differences in locating a target sound accompanied by a spatially disparate neutral light correlate with whether the two stimuli were perceived as spatially unified. This correlation suggests that internal representations are necessary for conscious perception, which may also mediate sensorimotor contingencies.

All of our information about the world is derived from the function of our senses, and thus they are the principal source of all our knowledge. This was recognized explicitly by early Greek philosophers, remained an important point of discussion for nineteenth‐century philosophers, and continues to be a key issue for present‐day philosophers, psychologists, and neuroscientists. It is a key issue in cognitive science because, by initiating the processes that store and evaluate information, sensory information transmission can be considered a (...) cognitive initiator. In a very real sense, who we are and how we see the world are the result of the experiences that are mediated by our sensory systems. These are some of the reasons why the study of sensory systems has occupied such a prominent place in modern cognitive neuroscience. (shrink)

One of the primary burdens of the mereological nihilist is accounting for our ordinary intuitions about material objects. It certainly *seems* as if I am typing on a keyboard, which has particular keys and buttons as parts. But such intuitions are mistaken if mereological nihilism is right, leading to widespread error. So nihilists often propose paraphrases of our everyday utterances as compensation. Cotnoir aims to deliver a new paraphrase strategy on behalf of the nihilist: one that interprets parthood and composition (...) modally, and interprets (spatial) parts as (modal) counterparts. He advertises this view as the spatial analog of Sider’s stage-theoretic view. Unfortunately, I argue, it isn't. The spatial analog to the above views would be something like the following: individuals are region-bound spatial bits. Certain spatial claims about these objects may be true if the relevant spatial bits have the appropriate spatial counterparts. The table is flat iff the table (a spatial bit) has a spatial counterpart that is flat. That is, spatial *counterparts* make certain spatial claims true. Call this the *bit-theoretic* view. In this paper, I use the bit-theoretic view as a foil for highlighting certain aspects of Cotnoir’s proposal, as well as to show that the very ways in which Cotnoir’s view differs from the bit-theoretic view are ways in which it undermines advantages of nihilism. (shrink)

This book is a rich blend of analyses by leading experts from various cultures and disciplines. A compact introduction to a complex field, it illustrates biotechnology's profound impact upon the environment and society. Moreover, it underscores the vital relevance of cultural values. This book empowers readers to more critically assess biotechnology's value and effectiveness within both specific cultural and global contexts.

It is widely recognized that ‘global’ symmetries, such as the boost invariance of classical mechanics and special relativity, can give rise to direct empirical counterparts such as the Galileo-ship phenomenon. However, conventional wisdom holds that ‘local’ symmetries, such as the diffeomorphism invariance of general relativity and the gauge invariance of classical electromagnetism, have no such direct empirical counterparts. We argue against this conventional wisdom. We develop a framework for analysing the relationship between Galileo-ship empirical phenomena on the one hand, and (...) physical theories that model such phenomena on the other, that renders the relationship between theoretical and empirical symmetries transparent, and from which it follows that both global and local symmetries can give rise to Galileo-ship phenomena. In particular, we use this framework to exhibit an analogue of Galileo’s ship for the local gauge invariance of electromagnetism. 1 Introduction2 Analogues of Galileo’s Ship? Faraday’s Cage and t’Hooft’s Beam-Splitter2.1 Faraday’s cage2.2 t’Hooft’s beam-splitter3 A Framework for Symmetries I: Systems and Subsystems4 An Example: Coulombic Electrostatics5 A Framework for Symmetries II: The Relationship between Theoretical and Empirical Symmetries6 Newtonian Gravity7 Local Symmetries that Are Not Boundary-Preserving: Classical Electromagnetism and Faraday’s Cage8 Local Boundary-Preserving Symmetries: Klein-Gordon-Maxwell Gauge Theory and t’Hooft’s Beam-Splitter9 Summary10 Conclusions. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

© 2014 Taylor Francis. The Centers for Disease Control and Prevention recommends routine human immunodeficiency virus testing of every client presenting for services in venues where HIV prevalence is high. Because older adults have particularly poor prognosis if they receive their diagnosis late in the course of HIV disease, any screening provided to younger adults in these venues should also be provided to older adults. We examined aging-related disparities in recent and ever HIV testing in a probability sample of at-risk (...) adults seeking services in needle exchange sites, sexually transmitted disease clinics, and Latino community clinics that provide HIV testing. Using multiple logistic regression with generalized estimating equations, we estimated associations between age category and each HIV testing outcome. Even after controlling for covariates such as recent injection drug use, older adults had 40% lower odds than younger adults did of having tested in the past 12 months or ever. Aging-related disparities in HIV testing exist among clients of these high HIV prevalence venues and may contribute to known aging-related disparities in late diagnosis of HIV infection and poor long-term prognosis. (shrink)

An exposition of Spinoza's views of the cause and cure of death. He holds death to be disruption of mind/body which need not involve becoming a corpse; amnesia counts. It follows that his criterion of personal identity includes memory, so Spinozistic immortality is impersonal. The cause of death is always something external, for nothing can destroy itself. (This principle, however, is not universally true; Spinoza was led to it by mistaken physics.) Suicide is irrational. Fear of death is to be (...) overcome by realization that since adequate ideas are eternal, to the extent that they consitute our minds we are eternal also. (But if so, isn't suicide rational after all? And since language depends on memory, the eternal understanding of adequate ideas is non-linguistic and non-symbolic; what then can it be?). (shrink)

For close to forty years now T.M. Scanlon has been one of the most important contributors to moral and political philosophy in the Anglo-American world. Through both his writing and his teaching, he has played a central role in shaping the questions with which research in moral and political philosophy now grapples. Reasons and Recognition brings together fourteen new papers on an array of topics from the many areas to which Scanlon has made path-breaking contributions, each of which develops a (...) distinctive and independent position while critically engaging with central themes from Scanlon's own work in the area. Contributors include well-known senior figures in moral and political philosophy as well as important younger scholars whose work is just beginning to gain wider recognition. Taken together, these papers make evident the scope and lasting interest of Scanlon's contributions to moral and political philosophy while contributing to a deeper understanding of the issues addressed in his work. (shrink)

Some students do not cheat. Students high in measures of bravery, honesty, and empathy, our defining characteristics of heroism, report less past cheating than other students. These student heroes also reported that they would feel more guilt if they cheated and also reported less intent to cheat in the future than nonheroes. We find general consensus between students and professors as to reasons for the nonreporting of cheating, suggesting a general impression of insufficient evidence, lack of courage, and denial. Suggested (...) interventions in academia are based in positive psychology and an understanding of academic heroes. (shrink)

Hegesias (3d c.BC), as hedonist, held that the sage will kill himself. For: One should pursue pleasure and avoid pain. But life is virtually certain to contain more pain than pleasure. Therefore death, which is neither pleasurable nor painful, is better than life. The flaw in the argument lies in the underlying game-theoretical model of life as a game in which play and payoff are distinct. Hegesias's conclusion, that life is not ‘worth living,’ is inescapable by any philosophy so based, (...) including John Rawls's. Why shouldn't his rational persons behind the veil of ignorance opt for prenatal suicide? (shrink)

The Moral Nexus develops and defends a new interpretation of morality—namely, as a set of requirements that connect agents normatively to other persons in a nexus of moral relations. According to this relational interpretation, moral demands are directed to other individuals, who have claims that the agent comply with these demands. Interpersonal morality, so conceived, is the domain of what we owe to each other, insofar as we are each persons with equal moral standing. The book offers an interpretative argument (...) for the relational approach. Specifically, it highlights neglected advantages of this way of understanding the moral domain; explores important theoretical and practical presuppositions of relational moral duties; and considers the normative implications of understanding morality in relational terms. The book features a novel defense of the relational approach to morality, which emphasizes the special significance that moral requirements have, both for agents who are deliberating about what to do and for those who stand to be affected by their actions. The book argues that relational moral requirements can be understood to link us to all individuals whose interests render them vulnerable to our agency, regardless of whether they stand in any prior relationship to us. It also offers fresh accounts of some of the moral phenomena that have seemed to resist treatment in relational terms, showing that the relational interpretation is a viable framework for understanding our specific moral obligations to other people. (shrink)

Reasons and Recognition brings together fourteen new papers on an array of topics from the many areas to which Scanlon has made path-breaking contributions, ...

T. M. Scanlon's magisterial book What We Owe to Each Other is surely one of the most sophisticated and important works of moral philosophy to have appeared for many years. It raises fundamental questions about all the main aspects of the subject, and I hope and expect that it will have a decisive influence on the shape and direction of moral philosophy in the years to come. In this essay I shall focus on four sets of issues raised by Scanlon's (...) systematic argument, with the aim of clarifying some of Scanlon's central assumptions and presenting alternatives at several key points. The perspective from which I offer these comments is that of a reader who is sympathetic to Scanlon's general approach but not yet convinced on various points of detail. (shrink)

According to T. M. Scanlon's buck‐passing account, the normative realm of reasons is in some sense prior to the domain of value. Intrinsic value is not itself a property that provides us with reasons; rather, to be good is to have some other reason‐giving property, so that facts about intrinsic value amount to facts about how we have reason to act and to respond. The paper offers an interpretation and defense of this approach to the relation between reasons and values. (...) I start by acknowledging the role that substantive values play in specifications of our reasons, noting that this poses an apparent challenge to the buck‐passing account. The challenge can be met, however, if we adopt a deliberative understanding of substantive value, an interpretation that I proceed to develop and defend. In conclusion I consider recent attempts to capture the agent‐relativity of reasons within a teleological framework for thinking about the relation between reasons and values. I argue that these approaches rest on a deliberative understanding of value; the teleological framework thus turns out to illustrate the basic insight of the buck‐passing approach, rather than offering an alternative to it. (shrink)

This is a preliminary version of an article to appear in the forthcoming Ashgate Companion to the New Philosophy of Physics.In it, I aim to review, in a way accessible to foundationally interested physicists as well as physics-informed philosophers, just where we have got to in the quest for a solution to the measurement problem. I don't advocate any particular approach to the measurement problem (not here, at any rate!) but I do focus on the importance of decoherence theory to (...) modern attempts to solve the measurement problem, and I am fairly sharply critical of some aspects of the "traditional" formulation of the problem. (shrink)

Wallace, Meg Once again, Fiji church leaders have raised objections to the establishment of a secular state based on erroneous representations of what secularism means - this time in Fiji. In what seems to be the first salvo in an election campaign leading up to the 2014 elections there, senior Catholic and Protestant clerics have come out against provisions in the recently adopted Constitution that declares Fiji a secular state, in which religion is deemed 'personal'. It was reported in (...) the Fiji News 7 December 2013 that 'the Catholic and Methodist Church do not think Fiji is ready for a secular state', declaring that religion is not a personal, but a public matter. (shrink)

Wallace, Max I respond here to David Nicholls November 2012 Facebook posting in response to my article 'Non-religious tax avoidance' in the Summer issue of AH, No. 108, 2012 where I reviewed how it was the Atheist Foundation of Australia came to have tax-exempt status and whether that was appropriate.

In lieu of an abstract, here is a brief excerpt of the content:Hume Studies Volume 28, Number 1, April 2002, pp. 83-111 Hume on Regulating Belief and Moral Sentiment KATHLEEN WALLACE There have been numerous discussions in recent years of Hume's general point of view. Some of the issues raised have been (1) Is the general point of view the moral point of view? (2) Is the general point of view necessary in order for a judgment to count as (...) a moral judgment? (3) Does the general point of view provide a justificatory perspective or is it a psychological explanatory concept that explains how moral judgments are made without necessarily offering a standard or normative basis for moral judgments? (4) If a general point of view yields some notion of impartiality, then how does it do so without introducing rationalistic elements that would undermine the sentimentalist approach Hume defends?1 In this paper I offer an interpretation of Hume's general point of view in morals as, employing a photographic analogy, a kind of focusing activity. It allows for strengthening of sentiments for those remote and, through contrariety, weakening of sentiments for those near such that we are moved to focus on those effects that are typical and, through conversing with others, arrive at general principles of praise or blame. I also examine the general point of view in comparison to what Hume has to say about regulation of belief. The comparison with belief sheds new light, I think, on how production of contrariety through the general point of view is regulative in morals. On my interpretation of the general point of view, it does not undermine Hume's sentimentalist thesis in morals, but rather is a device by which sentiment is properly aroused and directed. The comparison with the belief-regulating Kathleen Wallace is Professor of Philosophy, Hofstra University, Hempstead, NY115491000, USA. e-mail: [email protected] 84 Kathleen Wallace mechanism of Book 1 of the Treatise also suggests some ways in which Hume's treatment of the general point of view is part of a unified or systematic treatment of regulation, that for Hume regulation is itself a kind of virtuecognitive, passional, or moral.2 In what follows I will first briefly discuss the notion of regulation with respect to belief about matters of fact, that is, causal relations. This will be helpful in setting up the scope of regulation in morals, since the latter involves, but is not limited to, regulation of belief. The discussion of belief will be followed by a longer discussion of the general point of view and the issue of regulation in morals. Finally, I will draw explicit comparisons between the two kinds of regulation that both illuminate moral regulation and secondarily suggest that Hume has a unified treatment of regulation. 1. The Generalizing Propensity and General Rules In Treatise 1.3.13 Hume explicitly discusses what he calls "general rules" (T.3.13.7-12; SBN 146-50). Shou'd it be demanded why men form general rules, and allow them to influence their judgment, even contrary to present observation and experience, I shou'd reply, that in my opinion it proceeds from those very principles, on which all judgments concerning causes and effects depend. Our judgments concerning cause and effect are deriv'd from habit and experience; and when we have been accustom'd to see one object united to another, our imagination passes from the first to the second, by a natural transition, which precedes reflection, and which cannot be prevented by it. (T 1.3.13.8; SBN 147) There are two tendencies that Hume identifies under "generalizing." The first is an error-prone generalizing tendency of the imagination and the second is the tendency to form corrections, in the understanding to form general rules for regulating inferences. Hume calls both these tendencies species of "generalizing " because in each case the mind moves beyond what is immediately present before it and supplements with an idea or a device from its own activity.3 There is some debate among commentators about whether Hume makes a sharp distinction between reflective, deliberate generalizing (such as that involved in the formation of the rules by which to judge of causes and effects ) and... (shrink)

Wallace, Meg Article 18 of the Universal Declaration of Human Rights provides for 'freedom of religion and belief'. Don't get me wrong, it is an essential part of a democratic society that people can adopt and practice a religious or other life-stance belief of their choice. My concern is that, as it stands, Article 18 fosters the privileging of religious beliefs, hindering the equal right of others to exercise the same right. We can see the tyranny of forcing religion (...) on people by extremists in other countries, but even in liberal democracies, government involvement in religion is ubiquitous. (shrink)